251. Gene-Based Interferon-Beta Therapy for Experimental Autoimmune Encephalomyelitis
نویسندگان
چکیده
منابع مشابه
Gene-based intramuscular interferon-beta therapy for experimental autoimmune encephalomyelitis.
In contrast to serial injections of recombinant interferon-beta (IFN-beta) for long-term therapy of multiple sclerosis (MS), prolonged systemic delivery of proteins derived through in vivo gene transfer may provide a more clinically relevant alternative. Here we compare the therapeutic efficacies of electroporation (EP)-mediated intramuscular IFN-beta gene transfer with repeated alternate-day i...
متن کاملExperimental Autoimmune Encephalomyelitis
Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis (MS). MS is also named encephalomyelitis disseminata (ED). EAE has been also called experimental allergic encephalomyelitis, but the word `allergic` is more and more replaced by the word `autoimmune`. This has to do with the deeper understanding of the disease biology that has been gathered over the last ye...
متن کامل[Experimental autoimmune encephalomyelitis: crosstalk with immunology and therapy].
The immune network is a complex system comprising several types of inflammatory and regulatory cells. Autoimmune diseases occur because of dysregulation in host defenses caused by a cellular imbalance. The pattern of imbalance depends on the disease. Most autoimmune diseases are chronic, and the mechanism underlying this chronic nature is yet to be determined. Monoclonal antibody therapy is hig...
متن کاملExperimental autoimmune encephalomyelitis Experimental aspects of EAE
myelinating disease of the central nervous system (CNS) that takes a relapsing–remitting or a progressive course (reviewed in Refs 1,2). Its counterpart in the peripheral nervous system (PNS) is chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) (reviewed in Ref. 3). In addition, there are acute, monophasic disorders, such as the inflammatory demyelinating polyradiculoneuropathy t...
متن کاملPeptide-based immunotherapy of experimental autoimmune encephalomyelitis without anaphylaxis
Administration of peptide antigens in tolerogenic form holds promise as a specific treatment for autoimmune and allergic disorders. However, experiments in rodent autoimmune models have highlighted the risk of anaphylaxis in response to systemic peptide application once the aberrant immune response is underway. Thus, mice with clinical signs of experimental autoimmune encephalomyelitis (EAE) or...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2006
ISSN: 1525-0016
DOI: 10.1016/j.ymthe.2006.08.278